Abstract
Since the effect of CSII therapy on thermogenesis is not known, therefore resting metabolic rate (RMR) and FIT was measured by indirect calorimetry in 7 DC receiving CSII therapy and prae-meal insulin bolus and in 7 age-matched controls (C). Pump treatment for at least one week before the study resulted in normal fasting BG (DC vs C, mean±SE 3.9±0.4 vs 4.5±0.2 mmol/1), free insulin (67.9±21 vs 73.5±13 pmol/1), GH (109±49 vs 80±38 pmol/1), FFA (510±108 vs 482±107 μmol/1), beta-hydroxy-butyrate levels (110±35 vs 113±30 μmol/1). DC had fasting hypoglucagonaemia (32±13 vs 118±13 pg/ml, p<0.05). Postprandial changes after a standardised breakfast (C 60.3, DC 57.4 KJ/kg lean body wt.) of these metabolites and hormones were similar in C and DC, except for the lower postmeal nadir of FFA in DC (139±24 vs 352±62 μmol/1, p<0.05) and RMR was also normal (C 6.4±0.2, DC 5.9±0.4 KJ/kg lean body wt./60 min). FIT however, was significantly (p<0.05) higher in DC than in C (4.91±0.4 vs 3.07±0.66 KJ/kg lean body wt./180 min). In spite of optimal control, the “metabolic efficiency” was subnormal in DC as suggested by the higher FIT, which might have been due to the peripheral rather than portal delivery of insulin with this mode of therapy.
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Molnár, D., Soltész, G., Decsi, T. et al. INCREASED FOOD-INDUCED THERMOGENESIS (FIT) IN DIABETIC CHILDREN (DC) RECEIVING CONTINUOUS SUBCUTANEOUS INSULIN INFUSION (CSII) THERAPY. Pediatr Res 19, 1076 (1985). https://doi.org/10.1203/00006450-198510000-00049
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DOI: https://doi.org/10.1203/00006450-198510000-00049