Abstract
Since PT can be a first sign of precoc. puberty(PP), the aim of our study was to identify simple items in the first 6 mos of follow-up(F/U) that could predict if PT would evolve to PP.
30 girls with PT were studied. First evaluation included bone age(BA) basal E2,FSH,LH and Prl. GnRH was done in 12 and F/U BA in 22. Based on clinical outcome after F/U of 2±1y(m±sd), patients were divided into 2 groups(G): 1)invaried, decreased or regressed 2)Progressed to PP. Age at onset in G2(60±34mos) differed from those in G1(16±20mos;p < 0.005). LH was higher in G2(7±3uUI/ml vs 2.9±1.6;p < 0.001). FSH, although elevated, did not differ between G1 and 2. FSH/LH areas after GnRH and basal E2 did not differ. Initial BA was advanced(>2sd) in G2 but also in 21% of G1. In F/U an acceleration of BA and growth velocity was seen only in G2.
The following points may help in an early prediction of the evolution of PT:a)age of onset less than 3y is typical of PT, b) LH is increased only in those who progress to PP, c)advanced BA is typical of PP but since it may also be found in other cases(21%), an abnormally increasing BA during a short term F/U(6mos) is indication of an evolution to PP.
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Tenore, A., Quattrin, T., Lubrano, P. et al. 195 PROGNOSTIC SIGNS IN THE EVOLUTION OF PREMATURE THELARCHE (PT). Pediatr Res 19, 636 (1985). https://doi.org/10.1203/00006450-198506000-00215
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DOI: https://doi.org/10.1203/00006450-198506000-00215