Abstract
Nine children with PP (2 boys and 7 girls) have been treated with D.Trp6 LHRH microcapsules (3mg), given once per month, for a period of 6-12 months. Two of them had congenital adrenal hyperplasia, one had hypopituitary dwarfism with early pubertal development and 6 had idiopathic PP. In all, clinical improvement (decreasing breast size down to fullnes from adipocity,or decreasing testicular volume) became evident within two months of treatment. The changes in LH values (basal, during sleep and post IV LHRH), prior to, and 3-5 months of treatment with A,are given below (mean±SEM): mIU/ml.
The mean estradiol value (pg/ml) was 35±1.1 before, and 21±5.3 during A (p < 0.05). The mean testosterone value (μg/dl) was 257±20 before and 23±5 during A (p < 0.001). It is concluded that the A used in this study is effective in inhibiting puberty in boys and girls. It was very well accepted and there were no evident side effects except for temporary local pain. The lenght of treatment in our subjects does not allow a prediction of the effect on final height, but the clinical and hormonal data in hands are favorable.
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Dacou-Voutetakis, C., Sbokou, D., Tolis, G. et al. 186 TREATMENT OF PRECOCIOUS PUBERTY (PP) WITH A MONTHLY INJECTION OF D-Trp6 LHRH ANALOG (A). Pediatr Res 19, 634 (1985). https://doi.org/10.1203/00006450-198506000-00206
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DOI: https://doi.org/10.1203/00006450-198506000-00206
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