Abstract
16 girls and boys were treated for tall stature. Their height prediction was above 185 cm and 205 cm, respectively. The girls received 0.5 mg of ethinylestradiol(EE2)daily. The mean plasma level of EE2 was 596± 82(SE)ng/ml. The gonadotropins were suppressed from pubertal values (LH 1.8±1.0;FSH 1.8±1.9)to low infantile or not measurable levels (LH 0.6 to<0.3;FSH 0.9 to<0.3 μg/l). Estradiol(E2)was also suppressed to infantile values(29+ 13 pg/ml)while testosterone(T)remained unchanged (294±38 pg/ml). The sex hormone binding globulin(SHBG)increased 4-fold from pubertal values (7.7±1.3 μg/ml) to high levels as usually seen in late pregnancy (31.3±6.4 μg/ml). The boys were treated with 500 mg of testosterone oenanthate(TO)i.m. every 2 weeks. The mean plasma level of T was 10218 pg/ml ranging from 1760 pg/ml at day 13 to peak levels of 22380 pg/ml at day 4. The gonadotropins were suppressed to low infantile values or below the detection limit (LH 0.3 μg/l ;FSH 0.4 to 0.3 μg/1).The E2 levels remained within the normal male pubertal range (36±12 pg/ml). The SHBG in these patients decreased by 57% to 1.8±0.2 μg/ml below the normal male range (3.1±0.3 μg/ml). The mean T/SHBG ratio increased 5-fold from 1018 to 5676. - Androgen action in boys is best reflected by the T/SHBG ratio.SHBG indicates estrogen action in girls. It's measurement may help prevent overtreatment in estrogen replacement therapy in hypogonadal girls.
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Sinnecker, G., Stahnke, N., Stöver, A. et al. 181 EFFECTS OF ETHINYLESTRADIOL AND TESTOSTERONE 0ENAN-THATE ON PITUITARY GONADOTROPINS, GONADAL STEROIDS AND SEX HORMONE BINDING GLOBULIN IN PUBERTAL BOYS AND GIRLS TREATED FOR TALL STATURE. Pediatr Res 19, 633 (1985). https://doi.org/10.1203/00006450-198506000-00201
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DOI: https://doi.org/10.1203/00006450-198506000-00201