Abstract
The observation that oral testosterone (T) administration raises hair zinc (Zn) levels in children with constitutional growth delay has led us to study the hair, serum, and urine Zn concentrations before and after the intramuscular administration of T enanthate (300 mg/month) in 7 male children (15-18y) with Kallmann Syndrome (KS) (Table).
We have shown that growth hormone (GH) administration to hypopituitary children resulted in significant reduction in urinary Zn excretion and increase in hair Zn levels. Now we have found that male adolescents with KS are also Zn deficient and that T administration resulted in a remarkable reduction in the urinary excretion of Zn and significant increase in their hair and serum Zn levels. These observations support the concept that anabolic hormones like GH and T play an important role in Zn metabolism.
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Castro-Magaña, M., Angulo, M., Chen, S. et al. 167 ZINC STATUS IN PATIENTS WITH KALLMANN SYNDROME AND ITS RESPONSE TO TESTOSTERONE TREATMENT. Pediatr Res 19, 631 (1985). https://doi.org/10.1203/00006450-198506000-00187
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DOI: https://doi.org/10.1203/00006450-198506000-00187