Abstract
Recent study of Puschett et al. (Mineral Electrolyte Metab. 6:190, 1981) showed that infusion of bovine PTH at physiological dose (0.3-0.5 u/kg) in thyroparathyroidectomized dogs produced phosphaturia and a reduction in urinary Ca excretion, but no increase in urinary excretion or renal tissue content of cAMP, suggesting that some effects of PTH may be mediated by mechanisms other than cAMP. In order to assess whether similar phenomena can be observed in human, we infused human PTH, 1-34, at 0.3 u/kg and 3 u/kg in 5 normal adults and measured urinary cAMP (UcAMP), %TRP, Ca, Mg, Na, K, and plasma cAMP (PcAMP) in the next 3 hours. As shown in the table, PTH at 0.3 u/kg induced phosphaturia of a similar magnitude and a comparable urinary excretion of electrolytes to that of 3 u/kg but PcAMP and UcAMP were markedly different. After 0.3 u/kg, there was no rise in PcAMP, and a small rise in UcAMP indicating a difference in handling and production of cAMP after physiological and pharmacological dose of PTH.
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Suh, S., Ramanathan, S. 158 RENAL EFFECT OF PHYSIOLOGICAL AND PHARMACOLOGICAL DOSES OF HUMAN PTH, 1–34, IN MEN. Pediatr Res 19, 629 (1985). https://doi.org/10.1203/00006450-198506000-00178
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DOI: https://doi.org/10.1203/00006450-198506000-00178