Abstract
CT radioimmunoassays are hampered by the heterogeneity of the hormone that often causes results not consistent with clinical findings. For this reason a purification method based on reversed phase chromatography was developed and purified CT (pCT) measured in parallel with non purified CT (nCT) in the plasma of 145 normal children and adults in occasion of routine samples for minimal pathologies. Results ± SD in pg/ml were:
In addition in 11 athyreotic children aged 1 to 6 years nCT were 64.4±21 and pCT 52.4±21.6 pg/ml. The data show 1) newborns have significantly lower pCT compared to children (p < 0.01), 2) nCT/pCT ratio is higher in children than in adults (0.59 vs 0.26, p < 0.01),3) athyreotic patients have normal CT levels.
In conclusion higher levels of pure, and probably more active CT are present at time of active bone mineralisation independantly of the presence of the thyroid gland.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tato, L., Dorizzi, R., Avanzini, S. et al. 156 EVOLUTION OF PLASMA PURIFIED CALCITONIN LEVELS IN CHILDREN. Pediatr Res 19, 629 (1985). https://doi.org/10.1203/00006450-198506000-00176
Issue Date:
DOI: https://doi.org/10.1203/00006450-198506000-00176