Abstract
Little is known about beta-cell function in patients with advanced cystic fibrosis (CF). To study this 22 CF patients (12 males, 10 females, age 15.1 years (10-17 years)) who never had glucosuria were compared with 21 age and sex matched healthy children (controls). All controls had normal oral glucose tolerance tests (OGTTs), but 10 (45 per cent) of the CFs had abnormal CGTTs, 8 impaired glucose tolerance and 2 diabetic. The area under the glucose curves in CFs with normal OGTTs was larger than that of controls (p < .05). Insulin and C-peptide responses were reduced and delayed in all CFs. Abnormal HbAlc values (>6.4 per cent) were found in 7 (32 per cent) of the CFs, but in no controls. Insulin receptor-binding to erythrocytes was similar in CFs and controls. Islet cell antibodies were negative in all CFs and controls.
Conclusion: Abnormal beta-cell function is frequently present in CF. With increasing longevity of CF patients, this may represent an important problem.
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Garne, S., Petersen, W., Heilmann, C. et al. 153 BETA-CELL FUNCTION IN CYSTIC FIBROSIS. Pediatr Res 19, 629 (1985). https://doi.org/10.1203/00006450-198506000-00173
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DOI: https://doi.org/10.1203/00006450-198506000-00173