Abstract
EGF action is mediated by binding to specific plasma membrane receptors. Receptor binding is known to be influenced by hormones involving corticosterone and thyroxine. The EGF receptor population is heterogeneous regarding affinity with an increase in high affinity receptors with increasing age. We studied EGF receptors with regard to binding capacity and affinity in livers from adult male and female mice with or without testosterone treatment. Membranes from individual animals incubated with labeled EGF showed significantly higher binding in males and treated females than in control females. Ka and Bmax were calculated from Scatchard analysis of labeled EGF binding to pooled membranes incubated with increasing amounts of nonlabeled EGF.
Conclusions: 1) The sexual dimorphism of hepatic EGF receptors relates to both receptor affinity and capacity. 2) Testosterone treatment of females increases high affinity EGF receptor binding.
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Aim, J., Lakshmanan, J. & Fisher, D. 149 SEXUAL DIMORPHISM AND TESTOSTERONE EFFECTS ON LIVER EPIDERMAL GROWTH FACTOR (EGF) RECEPTORS IN MICE. Pediatr Res 19, 628 (1985). https://doi.org/10.1203/00006450-198506000-00169
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DOI: https://doi.org/10.1203/00006450-198506000-00169