Abstract
To examine the suggestion that adrenarche is independent from gonadarche we determined the 24h urinary excretion of 5 androgen metabolites by 14 patients with karyotypes 45,XO (group A) and by 8 patients with chromosomal mosaics or structural X abnormalities (group B) compared to 21 healthy girls (group C). Chronological ages: (median, range); A: 13.6, 2.9-18.1, B: 12.3, 9.2-20.7, C: 10.4, 5.6-15.1 years, respectively. Pubic hair: (median, range); A: 1, 1-3, B: 1-2, 1-4, C: 2, 1-5 stages, respectively. The method used consisted of Sep-pak extraction, enzymatic hydrolysis, derivative formation and capillary column gas chromatography. Statistics were done by multiple linear regression and Wilcoxon test.
Results: (mg/24h, median, max). In contrast to An and Et the excretion of DHEA and its metabolites was significantly higher in A and B compared to C.
Conclusion: The adrenarche in GD is comparable to healthy girls. In GD the elevated excretion of DHEA and its metabolites may be due to adrenal stimulation by an as yet unknown adrenal androgen stimulating hormone. Supported by DFG (Ho-471).
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Homoki, J., Wudy, S. & Teller, W. 105 ADRENARCHE AND URINARY EXCRETION OF ANDROGEN META-BOLITES IN GONADAL DYSGENESIS (GD). Pediatr Res 19, 621 (1985). https://doi.org/10.1203/00006450-198506000-00125
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DOI: https://doi.org/10.1203/00006450-198506000-00125