Abstract
Serum growth-promoting activity measured as 3H-THY incorporation into lymphocytes (TA) was measured simultaneously with RIA of IGFs I and II in the same samples of cord blood and of capillary blood collected 30 min. and 24 hrs after vaginal delivery in newborns (16 F, 17 M) with birth weight and length in the normal range. Values found in cord blood were lower than in normal adult serum: TA: 0.87±0.06 U/ml, IGF I: 45±3 ng/ml, and IGF II: 228±22 ng/ml. The values observed in the capillary blood at 30 min., more elevated than those in the cord blood, agree with a production of growth factors by the newborn. The 24 hrs evolution was discrepant: decreasing for IGF I (16± 1.8 ng/ml), unchanged for IGF II (260±28 ng/ml) and increasing above normal adult level for TA (1.84±0.22 U/ml). Each of these factors could play a role in the fetal growth, as suggested by the positive correlation (p < 0.05) observed between their levels and the birth weight. Non-IGF factors involved in TA play probably a major role in the neonatal period since they are higher in newborns than in adults.
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Schimpff, RM., Bozzola, M. & Zapf, J. 95 NEONATAL EVOLUTION OF IGFs AND SERUM THYMIDINE ACTIVITY. Pediatr Res 19, 619 (1985). https://doi.org/10.1203/00006450-198506000-00115
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DOI: https://doi.org/10.1203/00006450-198506000-00115