Abstract
Synthetic CRF 1-41 in a dose of 1 mcg/kg was administered i.v. Plasma cortisol (CO) and ACTH were determined before and at 30, 60, 90 & 120 min. Fourteen children (12M, 2F 12±4.8 yrs) were investigated including 2 normal controls, 6 with IGHD and 6 with MPHD. According to the peak plasma CO during ITT the subjects were classified into 2 groups: Gr. A - intact hypothalamic-pituitary-adrenal (HPA) axis (peak CO > 16 ug/dl; Gr. B - subnormal responders.
The CRF test made it possible to distinguish between a pituitary lesion (ACTH def.) and a hypothalamic defect (CRF def.). There was also a good correlation between the CRF, GH-RH and TRH tests in the same patients. It is concluded that the CRF test is a useful addition to the diagnostic endocrine armamentarium.
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Bauman, B., Pertzelan, A., Josefsberg, Z. et al. 87 EFFECT OF CRF 1–41 AS COMPARED TO INSULIN HYPOGLYCEMIA (ITT) ON PLASMA CORTISOL AND ACTH IN SUBJECTS WITH INTACT OR DEFECTIVE HYPOTHALAMIC-PITUITARY FUNCTIONS. Pediatr Res 19, 618 (1985). https://doi.org/10.1203/00006450-198506000-00107
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DOI: https://doi.org/10.1203/00006450-198506000-00107