Abstract
Each of three children in a family was found to be hypothyroid at birth as part of the neonatal hypothyroid screening program. Their mother had developed Graves disease at age 8 years but became hypothyroid at age 25 - 3 years before the 1st child. Serum obtained 6 years after the 1st child was born, inhibited TSH binding to human thyroid cell membranes in vitro. At birth each child was found to have increased TSH concentration. In retrospect thyroid microsomal autoantibodies were present at 1:6400 at 2 months of age in first boy and at 1:6400 at 3 days of age in third child. The oldest two children have been followed 3 months off thyroxine therapy and continue to have normal thyroid function (T4, unbound T4, T3 and TSH).
In patients with congenital hypothyroidism in whom the mother has autoimmune thyroiditis or there is a family history of thyroiditis, the possibility of a transient condition secondary to transplacental immunoglobulins should be sought.
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Francis, G., Riley, W. & Zakarija, M. 70 Familial Congenital Hypothroildism Secondary to Transplacental Thyroid Inhibitory Autoantibodies. Pediatr Res 19, 615 (1985). https://doi.org/10.1203/00006450-198506000-00090
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DOI: https://doi.org/10.1203/00006450-198506000-00090