Abstract
The low molecular form of somatomedin-binding protein (SMBP) in serum crossreacts in a radioimmuno-assay developed for the SMBP isolated from human amniotic fluid. The SMBP in medium conditioned by hepatoma cells, HEP G2, was isolated by use of immunoaffinity chromatography and shown to have a N-terminal amino acid sequence identical with the amniotic SMBP. The HEP G2 cells were used as a model for the regulation of SMBP and the result was compared with those in humans.
The levels of immunoreactive SMBP are tenfold higher in newborns than in adults, in which they are inverse related to GH. Increased levels are found during pregnancy and in patients with uremia. Estrogens increase the levels whereas GH causes a suppression.
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Póvoa, G., Hall, K. 51 REGULATION OF SOMATOMEDIN-BINDNING PROTEIN. Pediatr Res 19, 612 (1985). https://doi.org/10.1203/00006450-198506000-00071
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DOI: https://doi.org/10.1203/00006450-198506000-00071