Abstract
20 prepubertal GH-deficient children (C.A. 4.88-17.75yrs) were studied; 15 patients had isolated GH-deficiency, 5 had multiple pituitary hormone deficiencies, such as GH-ACTH-TSH (1 case), GH-TSH (2 cases), GH-LH-FSH-TSH (1 case) and GH-LH-FSH (1 case). In all patients synthetic human GH-RF (1-40) was administered i.v. at a dose of 3 μg/Kg at time 0 and blood samples for GH and HPRL were taken at -15,0,15,30,45,60,90,120 and 180 min; samples for TSH and ACTH were taken at 0,30,60,90 and 120 min, and for SmC at 0,30,60,120 and 180 min after injection. A significant GH-response (> 4ng/ml) was attained in 13 patients (11 with isolated GH-deficiency and 2 with multiple hormone deficiencies); GH levels increased at 15 min and reached a peak at 30 min. In these patients a significant increase in HPRL levels was observed after 15-30 min. In the whole group there were no changes in ACTH, TSH and SmC levels. The 7 patients who did not respond to GH-RF were not different with regards to age, sex, duration of treatment and response to the latter, from those who did respond. In our study a hypothalamic deficiency was present in 65% of the subjects. These data suggest that GH-RF could be useful in the treatment of a high percentage of GH-deficient patients.
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Cicognani, A., Pirazzoli, P., Natali, G. et al. 44 GH, HPRL, ACTH, TSH AND SmC RESPONSE TO GH-RF IN CHILDREN WITH PITUITARY DWARFISM. Pediatr Res 19, 610 (1985). https://doi.org/10.1203/00006450-198506000-00064
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DOI: https://doi.org/10.1203/00006450-198506000-00064