Abstract
54 patients (43 children) with GH deficiency documented by 2 GH secretion provocative tests (peak 5ng/m1) were given Iμg/kg/b.w. I.V. bolus of synthetic I-44 GRF (Generous gift from R.Guillemin, the salk Institut). Plasma GH and Prl were assayed from time O'to 120 GH deficiency was Idiopathic(IGHD.n=24)or secondary to a brain tumor (TGHD.n=30). 16 patients (7/24 IGHD+9/30 TGHD) displayed basal (B) hyperprolactinemia (Prl 450mUI/1).
The only positive correlations found were between Basal Prl and Prl, specially among B.hyperprolactinemics (r=0.62-p 0.005). Surprisingly no correlation was found in any group between B.Prl and GH nor Pr1 and GH. Some subjects displayed a Prl peak with no GH peak, others a GH peak and no Prl peak. This study confirms that GRF can induce a Prl rise. Vascular flush is not the only possible explanation. A Prl peak with no GH response suggests that GRF had reached the pituitary and non functionnal or atrophic Somatotrophs. Chronic GRF stimulation may be required to maintain or induce functionnal Somatotrophs. In GH deficiency. B.hyper-Prl cannot predict GH response to GRF. Asinle GRF injection cannot exclude GRF deficit.Prl is worthwile assaying after GRF.
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Catbeh, N., Chatelain, P., Sassolas, G. et al. 42 EFFECT OF ACUTE I.V. GROWTH HORMONE-RELEASING-FACTOR (GRF) ON PLASMA PROLACTIN(Pr1) IN GROWTH HORMONE(GH) DEFICIENT PATIENTS. Pediatr Res 19, 610 (1985). https://doi.org/10.1203/00006450-198506000-00062
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DOI: https://doi.org/10.1203/00006450-198506000-00062