Abstract
The effect of hGH treatment was studied in 21 prepubertal (12 M, 9 F) GH deficient children (14 IGHD, 7 MPHD) treated for 5 yrs. They were grouped according to age at start of therapy: Gr. A: CA 0.9-4.8, BA 1±1 y; Gr. B: CA 5.1-9.9, BA 3.8±2 y. The initial dose of hGH was 2-4 IU×3/wk.
In Gr. A the mean height SDS gain in the first year was 1.5 compared to 0.8 in Gr. B. In the 2nd year height SDS gain was 0.8 and 0.2 respectively. The SDS gains decreased with years of therapy. The bone age advancement was faster in Gr. B. It is concluded that initiation of hGH therapy in early age is most effective for height normalization, especially in isolated hGH deficiency.
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Josefsberg, Z., Bauman, B., Pertzelan, A. et al. 39 EFFICIENCY OF GROWTH PROMOTING ACTION OF hGH IS HIGHEST IN VERY YOUNG DEFICIENT CHILDREN. Pediatr Res 19, 610 (1985). https://doi.org/10.1203/00006450-198506000-00059
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DOI: https://doi.org/10.1203/00006450-198506000-00059