Abstract
Hypopituitary boys (n=29) treated with hGH (18 to 24 IU/week) were studied before and during spontaneous puberty (SP, n=9) or puberty induced with testosterone enanthate, 100 mg/month (TIP, n=20). At onset of puberty, bone age (BA, TW2) varied between 11.2 and 15.4 yrs. Total height gain during puberty (mean : 17.2 cm) was not significantly related (r=-0.38) to BA ot onset of puberty. In contrast, BA increment (ΔBA) during puberty was negatively related (r=-0.92) to BA at onset of puberty. Final height (FH) was attained in 21 out of 29 patients. Mean FH was 157.2 cm after SP and 165.5 cm after TIP. FH was a direct function of parent's height (r=0.61). After allowing for parent's height, FH was found to be significantly related to height at onset of puberty (r=0.71) and adult height predicted (TW mark II) at onset of puberty (r=0.81). In contrast, FH did not change in relation to BA at onset of puberty (r=0.28). At the end of growth, a decreased height velocity (HV) can be expected from previous HV (r=0.57) and from height achieved as a percentage of predicted FH (r=-0.56) but not from BA at that time.
We conclude that, in hypopituitary boys with SP and TIP, 1.BA at onset of puberty does not primarily influence HV during puberty and FH, 2. at onset of puberty, FH may be predicted although somewhat underestimated, 3. besides parent's height, the major factor influencing FH is patient's height at onset of puberty.
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Bourguignon, J., Vandeweghe, M., Vanderschueren-Lodeweyckx, M. et al. 26 PUBERTAL GROWTH AND FINAL HEIGHT IN HYPOPITUITARY BOYS ARE NOT RELATED TO BONE AGE AT ONSET OF PUBERTY. Pediatr Res 19, 607 (1985). https://doi.org/10.1203/00006450-198506000-00046
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DOI: https://doi.org/10.1203/00006450-198506000-00046