Abstract
An indirect immunofluorescence test revealing serum antibodies directed against human and guinea pig pituitary gonadotropic cells (AGC-A) was used in 46 cases of common cryptorchidism, 26 unilateral and 20 bilateral, without associated abnormalities. Among 23 patients aged 1 to 11 years, 14 had AGC-A, without correlation with age, uni or bilaterality, or the results of further hormonal investigations using LHRH and hCG stimulation tests. No AGC-A were found in 24 control boys of same ages. Among 23 cryptorchid infants aged 1-3 months, 12 had AGC-C, without correlation with their plasma levels of testosterone, LH and FSH; follow-up in 9 showed that AGC-A persisted in 7, disappeared in 2. Paired study was done in 15 newborns and mothers and was concordant in 14, 7 with and 7 without AGC-A. In spite of the discrepancies, the study of auto-immunity could improve the understanding of congenital testicular maldescent.
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Job, JC., Pouplard, A., Luxembourqer, I. et al. 13 ANTIGONADOTROPIC-CELLS ANTIBODIES IN THE SERUM OF CRYPTORCHID CHILDREN AND INFANTS AND THEIR MOTHERS. Pediatr Res 19, 605 (1985). https://doi.org/10.1203/00006450-198506000-00033
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DOI: https://doi.org/10.1203/00006450-198506000-00033