Abstract
To determine if serum TRAb measurements are useful in diagnosis and management of JGD, we studied 48 pts with JGD & 113 controls: 41 adults; 41 children & 31 with Hashimoto's Disease (HD), 9 with ↑ TSH levels. We tested 3 groups of JGD pts, I: active and untreated disease; II: recurrent disease; III: in remission on no therapy. TRAb was measured by displacement of labeled bTSH from porcine thyroid membranes (C1. Endocr. 20:539,1984), and values expressed as % inhibition of tracer TSH binding.
No antiidiotypic antibodies were detected. There was no correlation between TRAb and TSH in HD with ↑ elevated TSH. False negative TRAb results occurred in 2 JGD-I (7%) pts and 1 JGD-II (6%) pt; false positive TRAb results occurred in 6 JGD-III (17%) pts, and were not associated with relapse of the disease.
In conclusion: Abnormal TRAb values will confirm the diagnosis of JGD in > 90% of pts with hyperthyroidism, and are found in > 90% of JGD pts in relapse. TRAb values are greater at initial diagnosis than during relapse, probably reflecting a shorter duration and less severity of disease during relapse. Abnormal TRAb values during remission may result from TRAb without thyroid stimulation, or the development of co-existing HD.
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Foley, T., White, C. & New, A. 8 THYROTROPIN RECEPTOR ANTIBODIES (TRAb) IN PATIENTS WITH JUVENILE GRAVES DISEASE (JGD). Pediatr Res 19, 604 (1985). https://doi.org/10.1203/00006450-198506000-00028
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DOI: https://doi.org/10.1203/00006450-198506000-00028