Abstract
GRF was measured by RIA in the extracted plasma of 27 constitutionally short children given an oral dose of L-DOPA or aminoacid infusion (ornithine or arginine). After an overnight fast and one hour rest, basal GRF levels were 47±7 (SEM) pg/ml. In 5 children L-DOPA induced at 15 min. a GRF increase from 47±5 (SEM) pg/ml to 96±15 (SEM) pg/ml followed by a GH increase at 60 min. from 2±0.5 (SEM) ng/ml to 12±2 (SEM) ng/ml. In 4 others no increase in either GH or GRF occurred after L-DOPA. In these 9 children the peaks of GH and GRF were strongly correlated (r = 0.841, p < 0.001). On the opposite, the aminoacid-induced GH release was not preceded by a GRF rise but was followed by a GRF decrease from 51±10 (SEM) pg/ml to 27±4 (SEM) pg/ml, p < 0.02. We conclude that GH stimulation tests may act in two different ways and that GH levels could be involved in the feedback control of GRF secretion.
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Donnadieu, M., Brion, D., Tonon, MC. et al. 4 VARIATIONS OF PLASMA GRF LEVELS DURING GH STIMULATION TESTS IN CHILDREN. Pediatr Res 19, 604 (1985). https://doi.org/10.1203/00006450-198506000-00024
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DOI: https://doi.org/10.1203/00006450-198506000-00024