Abstract
To further understand pathophysiology for increased incidence of hyaline membrane disease seen in infants of diabetic women, a rabbit model was chosen to determine lung tissue PGL in hyperglycemic fetal rabbits in vivo: Hyperglycemia was induced by continuous infusion of D30 0.3% saline(Gr1)via a catheter introduced in femoral vein of a pregnant doe on the 26th day of gestation. After 46–18 hours of infusion C-hysterectomy was performed. Lungs were removed and analysed for total phospholipids and PGL. Serum insulin and glucose levels were determined on doe's and fetal blood. The data on 7 rabbit does in Gr1, 6 rabbit does in Gr2 and 7rabbit does in Gr3 are available. Both serum glucose and insulin were higher at delivery in does and fetuses in Gr1 compared to Gr2 and Gr3. As a % of TPL, PGL data were divided into <2% or >2% groups. There was no difference detected in any of the groups. There was no difference between Male(M)and Female (F)fetuses in relation to the different groups.
These data suggest that hyperglyoemia of about 6% of gestational time duration induced by infusion of highly concentrated dextrose solution, does not alter lung tissue PGL in fetal rabbit in vivo at 26 to 28 days of gestation.
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Patel, D., Rhodes, P., D'Cruz, C. et al. 1810 LUNG TISSUE PHOSPHATIDYL GLYCEROL(PGL)IN HYPERGLYCEMIC FETAL RABBITS IN VIVO. Pediatr Res 19, 412 (1985). https://doi.org/10.1203/00006450-198504000-01828
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DOI: https://doi.org/10.1203/00006450-198504000-01828