Abstract
Cdyn measurements within the first three days of life accurately predicted survival in 57 preterm infants with RDS. In 43 survivors (BW 1310+/−630g, GA 30+/-3wks) Cdyn was measured on 2.4+/−1.4 day of life and in 14 nonsurvivors (BW 1200+/−660g, GA 28+/−4 wks) on 2.7+/−1.7 day. All nonsurvivors died from respiratory failure in the first two weeks of life. Cydn of survivors was 0.83+/−0.37ml/cm and of nonsurvivors 0.45+/−0.25 ml/cm (p 0.01). With a Cdyn of 0.45ml/cm as a threshold for survival, 9/11 infants with Cdyn below this level died, and 41/46 with Cdyn above this survived for a specificity of 81% and a sensitivity of 89%.
Eight infants with pneumothorax (PT) had a Cdyn of 0.71+/−0.50ml/cm compared to 0.77+/−0.36ml/cm among 49 without PT. Four survivors with PT had a Cdyn of 1.08+/−0.48ml/cm compared to four nonsurvivors with PT whose Cdyn was 0,34+/−0.24ml/cm (p 0.05). A Cdyn of 0.45ml/cm predicted 3/3 deaths in infants with lower scores, and 4/5 survivals in those with higher measurements. In this subgroup specificity was 100% and sensitivity 80%.
Cdyn measurements during the first three days of life are useful in predicting outcome in infants with respiratory failure due to RDS.
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Novo, R., Smith, C., Graff, M. et al. 1807 THE USE OF DYNAMIC COMPLIANCE (CDYN) TO PREDICT SURVIVAL IN INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS). Pediatr Res 19, 412 (1985). https://doi.org/10.1203/00006450-198504000-01825
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DOI: https://doi.org/10.1203/00006450-198504000-01825