Abstract
Serial PFTs were performed in a baboon model to characterize changes during the course and recovery of HMD. Preterm baboons delivered abdominally at 140±2 days gestation were intubated at birth and stabilized. An esophageal balloon was inserted. The anesthetized, paralyzed animals were placed in a constant volume pressure plethysmograph for PFTs. Dynamic compliance (Cdyn) at 0.5 Hz, total lung resistance (RL), inspiratory capacity (IC) at 30 cmH2O pressure, static compliance (Cst) and functional residual capacity (FRC) by helium dilution were measured. Mean values (±SD) obtained were: (Paired t–test).
Significant (P<0.05) improvement occurs in FRC by day 1; IC, Cst and Cdyn by day 3; and RL by day 9. Serial PFTs may serve as a basis for evaluating complications and therapy for HMD.
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Montes, M., Escobedo, M., Boyd, R. et al. 1802 PULMONARY FUNCTION TESTS (PFTs) IN PRETERM BABOONS WITH HYALINE MEMBRANE DISEASE (HMD): PROGRESSION AND RECOVERY. Pediatr Res 19, 411 (1985). https://doi.org/10.1203/00006450-198504000-01820
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DOI: https://doi.org/10.1203/00006450-198504000-01820