Abstract
Caffeine therapy improved the pneumocardiogram(PCG) performance of nine infants monitored for prolonged apnea. The patients (BW 1.8+/−0.4 kg, GA 32+/−2 weeks), were examined with a twelve hour PCG at 6.5+/−9.0 weeks of age. Oral caffeine citrate was then started with a loading dose of 20 mg/kg, followed by a daily maintenance dose of 5/mg/kg. A second twelve hour PCG was obtained at 10.0+/−9.0 weeks. All PCG's were read by a computerized analyzer (Medical Graphics). The results of the comparison are shown below:
The PCG following caffeine administration showed fewer short (<15 sec) and long apneas (> 15 sec), decreased apnea density, and decreased episodes and percent of PB. Caffeine did not influence number, length, or nadir of associated bradycardias. Caffeine therapy was effective in decreasing the severity of the documented abnormalities in ventilatory control in this group of infants.
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Mondestin, H., Mojica, N., Hiatt, I. et al. 1801 THE EFFECT OF CAFFEINE IN INFANTS MONITORED FOR PROLONGED APNEA. Pediatr Res 19, 411 (1985). https://doi.org/10.1203/00006450-198504000-01819
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DOI: https://doi.org/10.1203/00006450-198504000-01819