Abstract
Naloxone therapy improved the pneumocardiogram (PCG) results of seven preterm infants suffering from apnea of prematurity. The patients (BW 1.5+/−0.2 kg, GA 32+/−2 weeks), were evaluated with a six hour PCG at 1.0+/−0.7 weeks of age. A single intravenous dose of naloxone, 0.01mg/kg, was administered, and then followed by a second six hour PCG. All PCG's were read by a computerized analyzer (Medical Graphics). The results of the comparison are shown below:
The PCG following naloxone administration had fewer short (< 15 sec) and long apneas (>15 sec), decreased apnea density and percent periodic breathing. Naloxone did not influence number, length, or nadir of associated bradycardias. Naloxone therapy was effective in decreasing the severity of clinical apnea in this group of infants.
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Mojica, N., Mondestin, H., Hiatt, I. et al. 1799 THE EFFECT OF NALOXONE ON APNEA OF PREMATURITY. Pediatr Res 19, 410 (1985). https://doi.org/10.1203/00006450-198504000-01817
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DOI: https://doi.org/10.1203/00006450-198504000-01817