FRC, related to alveolar stability at end expiration, would be expected to improve with recovery from HMD. Intubated, paralyzed preterm (140±2 days) baboons with HMD were evaluated with serial FRC measurements by the He dilution method on Day 0, 3, 7 and 9. Values on Day 0 were obtained within 4 hrs. of birth when all animals were ventilated by conventional ventilation (CV). Animals were then randomized to CV or high frequency ventilation (HFV). Mean values (±SD) obtained were:
On Day 0, FRC was not significantly different (ANOVA for repeated measures) between ventilator groups indicating groups of equivalent initial disease severity. Analysis of differences due to ventilator type and interaction between ventilator type and time proved nonsignificant. FRCs on Day 3, 7 and 9 were significantly improved (P< 0.01) over Day 0 values. Changes in FRC appear to reflect recovery in surviving preterm baboons with HMD treated with CV or HFV.
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Caballero, R., Escobedo, M., Montes, M. et al. 1737 FUNCTIONAL RESIDUAL CAPACITY (FRC) CHANGES IN PRETERM BABOONS WITH HYALINE MEMBRANE DISEASE (HMD). Pediatr Res 19, 400 (1985) doi:10.1203/00006450-198504000-01755