Abstract
Long-term neurodevelopmental sequelae of chronic disorders such as bronchopulmonary dysplasia (BPD) have not been well-documented in relation to acute perinatal insults such as intracranial hemorrhage (ICH). To study this relationship in ≤1,200 gm infants, the present study used repeated ultrasonographic scans at bedside to detect ICH prior to hospital discharge, and defined BPD as more than 3 wks of ventilation. 68 ≤1,200 gm infants born between 4/14/80 and 4/14/83 were followed through at least 12 mo. of age, with 48 infants tested thus far at 24 mo. (corrected for prematurity). Mean Bayley mental and motor scores at 12-24 mo. were:
Both ICH groups included 4 grade III–IV survivors. A repeatedmeasures ANOVA revealed significantly poorer mental and motor performance by BPD infants through 18 mo. of age (ps<.02). ICH resulted in poor motor performance, but just in nonBPD infants (p<.05). Only BPD substantially depressed mental scores (p<. 05).
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Nelson, M., Bozynski, M., Matalon, T. et al. 54 TWO-YEAR FOLLOW-UP OF BRONCHOPULMONARY DYSPLASIA AND INTRACRANIAL HEMORRHAGE IN ≤ 1,200 GM INFANTS. Pediatr Res 19, 119 (1985). https://doi.org/10.1203/00006450-198504000-00084
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DOI: https://doi.org/10.1203/00006450-198504000-00084