Abstract
We examined the ventilatory response to carbon dioxide in 58 infants at risk for disturbances of ventilatory control. Eight siblings (BW 3285±410g) were tested at 11.6±14.0 weeks, 25 near-miss infants (BW 3220±680g) at 13.0±12.0 wks., 10 preterm infants (BW 1780±750g) with prolonged apnea at 14.3±10.8 wks., 9 term infants (BW 3120 ±81.0g) with cyanosis at 6.2±6.0 wks., and six infants (BW 3370±820g) with reflux at 12.0±7 wks. The responses from baseline (B) to 4% carbon dioxide are shown below:
There were no differences in the Ve changes among the groups, however, the frequency response was significantly decreased in the sibling and cyanotic infants. These results point to the heterogeneity of infants at risk for abnormalities of ventilatory control, whereby different mechanisms may be responsible for responses to physiologic stimuli.
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Graff, M., Novo, R., Smith, C. et al. 1400 FREQUENCY AND TIDAL VOLUME CHANGES IN HIGH RISK IN FANTS IN RESPONSE TO INHALED CARBON DIOXIDE. Pediatr Res 19, 344 (1985). https://doi.org/10.1203/00006450-198504000-01424
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DOI: https://doi.org/10.1203/00006450-198504000-01424