Abstract
D deficiency rickets has been reported mainly in black infants, and we have reported lower serum 25-hydroxyvitamin D (25-OHD) in black vs white infants. We hypothesized that race dependent differences in the response of D metabolites to chronic SE UVB may explain these observations. Prior to infant studies, we determined the responses of serum 260HD, 24, 25-dihydroxyvitamin D (24, 25(OH)2D) and 1, 25-dihydroxyvitamin D (1,25(OH)2D) to total body SE UVB given twice weekly for 6 weeks in 13 whites (W) and 7 blacks (B) age 20-35 yrs. Results as mean ± SEM; *P<0.001 vs baseline; †P<0.05 blacks vs whites; t-test.
250HD and 24,25(OH)2D) are lower in blacks vs whites; the increases in 250HD and 24,25(OH)2D are independent of baseline values or race. 1.25(OH)2D is similar in both groups and does not change during the study. Thus, race dependent differences in the response of D metabolites to SE UVB do not explain reported differences in D metabolite levels. We speculate that other factors such as duration or extent (surface area) of natural UVB exposure may explain the reported racial differences in D metabolites.
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Brazerol, W., McPhee, A., Estes, S. et al. 1197 RESPONSE OF VITAMIN D METABOLITES TO CHRONIC SUBERY THEMAL ULTRAVIOLET B (SE UVB) EXPOSURE IN BLACKS VS WHITES. Pediatr Res 19, 310 (1985). https://doi.org/10.1203/00006450-198504000-01227
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DOI: https://doi.org/10.1203/00006450-198504000-01227