Abstract
Twenty patients with Gram-positive CVC infections were treated with intravenous vancoroycin and rifampin: pharmacokinetics were determined serially in 12, aged 3 mos. to 12 yrs. Plasma clearance (Clp) did not correlate with age, but did correlate with VD and peak conc, with increasing duration of therapy Clp increased 58* (3.24 to 5.12 l/hr/m2) and T½ decreased 27% (2.48 to 1.81 hrs), although interpatient Clp ranged from 1.49 to 8.58 1/hr/m2. The peak conc, correlated with Clp. The reciprocal of the predicted dose corrected conc, at the average mean residence time (MRT) (3.14 hrs) correlated (r=0.918) with measured Clp. Measured rifampin conc, at the MRT predicted Clp. The CVC was removed from 3 patients before the 14 day treatment concluded; 15 patients were free of CVC infection 30 days after concluding therapy. Persistence of infection occurred in 1, superinfection in 1. We conclude that vancomycin and rifampin is efficacious therapy for CVC infections. Increasing Clp of rifampin necessitates periodic dosage adjustment, but Clp can be predicted from the measured rifampin cone, at the MRT.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Koup, J., Williams-Warren, J., Weber, A. et al. 1123 Efficacy and pharmacokinetics of intravenous rifampin for central venous cannula (CVC) infections.. Pediatr Res 19, 298 (1985). https://doi.org/10.1203/00006450-198504000-01153
Issue Date:
DOI: https://doi.org/10.1203/00006450-198504000-01153