Abstract
A prospective study of diarrhea associated with AMI is being conducted in Houston, TX. Infants (n=459) less than 3 mo of age have been enrolled in the study (10-1-80 to 10-1-83). A stool specimen was collected from each patient and tested for rotavirus by Rotazyme®. Forty-six percent of the infants had acute diarrheal syndrome (ADS),(diarrhea < 14 days duration), 45% had chronic diarrhea (CD), (diarrhea > 14 days duration), and 9% had AMI, a form of chronic diarrhea which occurs after feeding any dietary carbohydrate. Mean age at admission (days) was 37 for ADS, 42 for CD, and 31 for AMI. The average duration of acute diarrheal symptoms prior to admission was 3.3 days for ADS, 5.9 for CD, and 5.1 for AMI infants. The weight change (g/d) from birth was 11.9 for ADS, 7.1 for CD, and -1.7 for AMI infants. Rotavirus was detected in the stools of 15% of ADS, 10% of CD, and 30% of the AMI infants. These findings suggest that rotavirus may be associated with the development of monosaccharide intolerance. A chronic state of malnutrition, however, may play a primary role in the development of monosaccharide intolerance.
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Nichols, V., Fraley, J., Klish, W. et al. THE RELATIONSHIP OF ROTAVIRUS TO ACQUIRED MONOSACCHARIDE INTROLERANCE (AMI) IN YOUNG INFANTS. Pediatr Res 18 (Suppl 4), 206 (1984). https://doi.org/10.1203/00006450-198404001-00681
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DOI: https://doi.org/10.1203/00006450-198404001-00681