Abstract
We have previously shown that malnutrition hastens the onset of mucosal pandisaccharidase deficiency (PDD) in the experimental blind loop model (Pediat. Res. 16, 177A, 1982). Since malnutrition may reduce the sIgA response and possibly encourage the growth of selective pathogens, we studied mucosal and luminal sIgA in experimental blind loops from nourished (N) and malnourished (MN) rats at varying time periods corresponding to the evolution of PDD. Self-filling (SFBL) and self-emptying (SEBL) blind loops were formed 7 cm distal to the ligament of Treitz. MN received 50% of the ad libitum intake consumed by littermates. Antibody to (N) rat sIgA was purified by affinity chromatography on Sepharose 4B linked sIgA. SIgA was determined by ELISA. N developed PDD at 4 weeks and MN at 1 week. Mucosal sIgA in N was unchanged for 8 weeks. In MN mucosal sIgA was significantly reduced at 1 week (p<.025), but not subsequently, although mean values were consistently lower than in N. In N blind loops, luminal sIgA rose 9.5 × to 17 × the sIgA levels in comparable segments of non-operated intestine at 1, 2 and 4 weeks. In MN, comparative levels of luminal sIgA were significantly lower at 1 week (p<0.005) and 4 weeks (p<0.05). There was no change in mucosal and luminal sIgA in SEBL. MN therefore slows and reduces sIgA accumulation in SFBL. A blunted immune response may hasten the evolution of PDD.
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Lichtman, S., Sherman, P., Underdown, B. et al. MUCOSAL AND LUMINAL IgA IN EXPERIMENTAL BACTERIAL OVERGROWTH. Pediatr Res 18 (Suppl 4), 204 (1984). https://doi.org/10.1203/00006450-198404001-00666
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DOI: https://doi.org/10.1203/00006450-198404001-00666