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SERUM LIPID ABNORMALITIES AFTER SUCCESSFUL RENAL TRANSPLANTATION (TX)

Abstract

Hyperlipidemia (HL) with increase in triglycerides (TG) is frequently seen in uremic patients before TX. In order to assess the lipid abnormalities following renal TX, 22 patient (15 females) x̄ age 17 years (range 5-21), with a functioning renal allograft (serum creatinine x̄ 1.13 mg/dl, range 0.7-2.6) were studied at x̄ 26 months (range 2-55) after renal TX. Serum total cholesterol (TC), TG, and lipoproteins VLDL, LDL and HDL were determined and compared to normal age and sex matched controls. Results (x̄ mg/dl ± SD) are shown in table (†p <0.01).

TC and TG were >95 percentile in 68% and 32% of the patients respectively. A significant correlation between HL and daily Prednisolone dose was found (r=0.55; p <0.01). These results demonstrate: 1) HL is commonly present following renal TX;2)HL is mainly due to increased TC, but with a significant elevation of HDL and maintenance of normal HDL/LDL ratios. Based on the findings of normal HDL/LDL ratios, the presence of HL following successful renal TX in children may not increase their risk of premature atherosclerosis.

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