Abstract
Summary: Phototherapy results in the conversion of bilirubin to more water-soluble isomers. Six clinically used phototherapy lamps which differ in their emission spectra have been compared in their ability to produce configurational and structural isomers of bilirubin in vitro. For all of the lamps, the initial rate of configurational isomerization was highly correlated (r = 0.969) with the intensity of irradiation falling within the bilirubin absorption band. The percentage of the total bilirubin converted to the configurational isomer at equilibrium was dependent upon the spectral distribution of the lamp, and was greatest (26.2 ± 1.3%) with the special blue lamp, which has a narrow spectral output centered at 445 nm. The rate of formation of the structural isomer, lumirubin, was generally dependent upon the intensity of irradiation within the bilirubin absorption band.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ennever, J., Sobel, M., Mcdonagh, A. et al. Phototherapy for Neonatal Jaundice: in Vitro Comparison of Light Sources. Pediatr Res 18, 667–670 (1984). https://doi.org/10.1203/00006450-198407000-00021
Issue Date:
DOI: https://doi.org/10.1203/00006450-198407000-00021
This article is cited by
-
Early formation of bilirubin isomers during phototherapy for neonatal jaundice: effects of single vs. double fluorescent lamps vs. photodiodes
Pediatric Research (2015)
-
Spectral matching research for light-emitting diode-based neonatal jaundice therapeutic device light source
Applied Physics B (2015)
-
Evaluation of phototherapy devices used for neonatal hyperbilirubinemia
Indian Pediatrics (2011)
-
On the efficacy of various irradiation regimens in phototherapy of neonatal hyperbilirubinaemia
European Journal of Pediatrics (1988)
-
Renal handling of bilirubin photoderivatives
Experientia (1987)