Abstract
Summary: The plasma concentrations of 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2D), and 24,25-dihydroxyvitamin D (24,25-(OH)2D) were determined pre-and postexchange, and in donors' blood in 10 blood exchange transfusions with citrated blood for neonatal hyperbilirubinemia.
The postexchange concentrations of 25-OHD and 24,25-(OH)2D were intermediate between the levels before exchange and in donors' blood. Before therapy, the 1,25-(OH)2D concentrations were higher in the infants' than in donors' blood, and the pre-exchange levels were re-established during the procedure.
The results suggest that postexchange concentrations of 25-OHD and 24,25-(OH)2D could be explained on the basis of redistribution of the metabolites between plasma and extravascular pools, whereas de novo synthesis was the most likely cause for the restoration of 1,25-(OH)2D levels.
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Markestad, T., Aksnes, L., Finne, P. et al. Effect of Exchange Transfusions with Citrated Blood on Plasma Concentrations of Vitamin D Metabolites in Neonates. Pediatr Res 18, 429–431 (1984). https://doi.org/10.1203/00006450-198405000-00007
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DOI: https://doi.org/10.1203/00006450-198405000-00007