Abstract
Nebulized racemic epinephrine is commonly used to improve ventilatory function in the newborn post extubation. To evaluate this therapy, 44 infants intubated for >3 days [mean 17.2±16.1 days (S.D.)] were studied. Infants were randomized to receive racemic epinephrine by nebulization immediately post extubation or to receive only warmed, humidified oxygen. Measurements of air flow (V), esophageal pressure (Pes), tidal volume (VT), respiratory rate (RR), and heart rate (HR) were made before treatment (immediately post extubation) and every 10 minutes for one hour. Changes from baseline values were calculated for each time period and analysis of variance of these variables for treatment, sex, and time main effects and their interactions, with appropriate adjustment for covariables, were performed. There were no significant time effects or interactions. The table presents mean ±1 S.D. changes over time for each treatment-sex group.
This study provides no evidence that using nebulized racemic epinephrine in infants post extubation improves ventilatory function.
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Courtney, S., Wachtl, J., Hopson, J. et al. EFFECT OF RACEMIC EPINEPHRINE ON VENTILATORY FUNCTION IN THE NEONATE POST EXTUBATION. Pediatr Res 18 (Suppl 4), 388 (1984). https://doi.org/10.1203/00006450-198404001-01773
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DOI: https://doi.org/10.1203/00006450-198404001-01773