Abstract
In previous studies, we have shown that DMSO reduces proteinuria in passive Heymann nephritis (PHN). We have now extended these studies to include the use of colchicine (C), a known inhibitor of microtubule function. In addition, colchicine alters the shape of glomerular epithelial cells. Rats were treated with saline (controls) or C (0.05 mg/kg/d i.p. × 28 days). Controls excreted 105 ± 22 and C-treated rats, 37 ± 6 mg/d, p <0.05. Onset of treatment during the autologous phase did not reduce proteinuria. Concomittant treatment with indomethacin abolished the beneficial effect of C. Whereas low doses of DMSO alone, and C alone reduced proteinuria, a combination of the same doses of C plus DMSO provided no added advantage over each alone. These studies demonstrate that C and DMSO can reduce proteinuria in PHN possibly via a common mechanism. We have thus identified two probes which may be useful in studying the pathogenesis of proteinuria in this model.
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Milner, L., Lotan, D., Goodyer, P. et al. COLCHICINE AND DMSO AS PROBES FOR STUDYING PROTEINURIA IN PASSIVE HEYMANN NEPHRITIS. Pediatr Res 18 (Suppl 4), 366 (1984). https://doi.org/10.1203/00006450-198404001-01636
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DOI: https://doi.org/10.1203/00006450-198404001-01636