Abstract
9 CF patients (15 to 18 years old;Schwachman score 80-90)and 7 control subjects (C) matched for age were investigated for glomerular function (Clin (min 1.73sqm)Na, HCO3- urinary ecretion;Na HCO3- distal delivery (DD:CH2O+CNa;CH2O+CHCO3-)during maximal water diuresis (I)and with isotonic saline infusion (4 ml/kg/min, II).Comparison between groups was performed by the Student t test Results;mean (± SD)
These data show that proximal tubular reabsorption of both Na and HCO3 is increased in CF.
No difference was found in distal tubular function studied by measuring the urinary excretion of NH4+ and percentage of Na distal reabsorption.
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Marra, G., Tirelli, S., Cavanna, G. et al. RENAL FUNCTION IN CYSTIC FIBROSIS (CF). Pediatr Res 18 (Suppl 4), 365 (1984). https://doi.org/10.1203/00006450-198404001-01632
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DOI: https://doi.org/10.1203/00006450-198404001-01632