Abstract
Atriopeptins I and II (AP-I, AP-II), 2 low mol. wt. peptides isolated from rat atria, cause specific relaxation of only intestinal smooth muscle (the 21-amino acid peptide AP-I) or both intestinal and vascular smooth muscle (the 23-AA peptide AP-II). Renal arterial injection of AP-II, but not AP-I, produces renal vasodilation. Both substances, as well as a high mol. wt. precursor, cause dose-related natriuresis and general increases in GFR when injected IV into anesthetized rats. The data below compare control (C) and experimental (E) periods of 10 min.
Partial purification of rabbit atrial homogenate yields high and low mol.wt. peptides which cause natriuresis. Low dose trypsin (lU/ml) activation of HMW produces a substance which is spasmolytic and natriuretic but does not increase GFR.
The data suggest that the atriopeptins exert a direct effect on the kidney tubule in addition to the vasodilatory effects.
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Cole, B., Boylan, J., Kuhnline, M. et al. ATRIOPEPTINS: NATRIURESIS OCCURS INDEPENDENT OF VASCULAR EFFECTS. Pediatr Res 18 (Suppl 4), 359 (1984). https://doi.org/10.1203/00006450-198404001-01599
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DOI: https://doi.org/10.1203/00006450-198404001-01599