Abstract
We studied the effects of exogenous surfactant (S-TA,Fujiwara) on the course of HMD in baboons delivered at 76% of term, 100 mg/kg of S-TA in saline was instilled via the E-T tube in 5 animals (Group S) at 2.0 hrs. of age; 3 animals were controls. Blood gases, lung compliance (CL) and mean airway pressure (MAP) were measured for 16 hrs. (Table:x̄±SD, *p<0.02, **p<0.01). Variables were identical before therapy. Pre-treatment values of CL 0.14, a/APO2 0.19 increased in S. Grp. within 30 minutes (p<.001), to improve and were increased to 0.34 and 0.45, respectively at 16 hrs.; in C Group they were 0.13 and 0.23 at 16 hrs. (p<0.02). Pulmonary pressure volume curves obtained at autopsy showed: in S Group at 5, 10 and 30 cms of H2O distending pressure 12, 15 and 20 ml volumes were achieved (deflation) but in C Group they were only 1.2, 2.5 and 5.7 mls. (p<0.001). Our results sueeest S-TA significantly improves CL, blood gases, and x-ray changes of HMD.
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Maeta, H., Raju, T., Bhat, R. et al. A CONTROLLED STUDY OF SURFACTANT TA IN PRETERM BABOONS WITH HMD. Pediatr Res 18 (Suppl 4), 353 (1984). https://doi.org/10.1203/00006450-198404001-01563
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DOI: https://doi.org/10.1203/00006450-198404001-01563