During a 19 day period in 1982, 4 of 12 infants in an NICU room at the University of Illinois developed hyperbilirubinemia with or without thrombocytopenia, fever or respiratory distress. Each of the 4 infants was viruric with CMV. All 4 were premature (gestational ages 26-31 weeks), were at least 1 month old at onset of symptoms (range 36-79 days) and had received multiple transfusions of packed red blood cells (range 4-11 transfusions; 94-150 cc total volume). Although the mothers of all 4 infants had IgG to CMV, none had anti-CMV IgM; cervical cultures were obtained from 2 of the 4 mothers, and CMV was not recovered. BamHl restriction-endonuclease analysis of all 4 CMV isolates showed identical banding patterns in the CMV's of 2 infants who had received blood from a common donor. The other 8 infants were followed for acquisition of CMV; none developed viruria. Of the 11 female health-care personnel in closest contact with the CMV-infected infants, 2 had anti-CMV IgG, but neither showed rises in titer or developed anti-CMV IgM. The other 9 remained seronegative 1 month following their exposure. Restriction-endonuclease analysis, used here in conjunction with conventional epidemiology indicates a low risk of CMV transmission from infected, tertiarycare NICU infants to other neonates or to health-care personnel.
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Tolpin, M., Stewart, J., Warren, D. et al. MOLECULAR EPIDEMIOLOGY OF ACQUIRED CYTOMEGALOVIRUS (CMV) DISEASE IN A NEONATAL INTENSIVE CARE UNIT (NICU). Pediatr Res 18, 287 (1984). https://doi.org/10.1203/00006450-198404001-01165