Abstract
Summary: Standard phototherapy illumination of human cells in the presence of riboflavin is known to produce single-strand breaks in intracellular DNA. A new photochemical reaction is described between riboflavin and purified DNA in which an adduct is formed. Unlike the previously described oxygen-dependent reaction between light-activated riboflavin and deoxyguanosine, this new photochemical reaction is oxygen-independent and involves deoxyadenosine or thymidine.
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Ennever, J., Speck, W. Short Communication. Photochemical Reactions of Riboflavin: Covalent Binding to DNA and to Poly (dA) · Poly (dT). Pediatr Res 17, 234–236 (1983). https://doi.org/10.1203/00006450-198303000-00014
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DOI: https://doi.org/10.1203/00006450-198303000-00014