Abstract
Previous studies correlating lymphocyte blast transformation and various in vivo manifestations of food protein intolerance have produced conflicting results. We compared the incorporation of H3 thymidine into lymphocytes cultured with each of 3 food protein antigens (cow-milk, soy, egg) with the response to acute oral challenge in a group of infants (<1 year old) with a history of enterocolitis. Challenges were performed and evaluated as previously described (J. Ped. 93:533) at least 1 month after recovery from enterocolitis. In 6 infants with negative responses to all three oral challenges, the mean stimulation index with no difference between antigens. The mean SI for 3 patients with positive oral challenges to soy was 13.7 and for 6 patients with positive oral challenges to cow milk, 6.1. Both values were significantly higher than the respective SI's in the negative oral challenge group (p<.02). The magnitude of the in vitro response correlated with the antigens responsible for positive oral challenges. These data suggest that infants with a well defined food protein-induced enterocolitis have blood lymphocytes sensitized to the specific antigens. A pathogenic role for these lymphocytes remains to be demonstrated.
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Van Sickle, G., Powell, G., Goldbium, R. et al. 653 FOOD PROTEIN-INDUCED ENTEROCOLITIS: CORRELATION BETWEEN ORAL CHALLENGE AND LYMPHOCYTE TRANSFORMATION INDUCED BY SPECIFIC FOOD PROTEINS. Pediatr Res 15 (Suppl 4), 549 (1981). https://doi.org/10.1203/00006450-198104001-00666
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DOI: https://doi.org/10.1203/00006450-198104001-00666