Abstract
40 children (27 F and 13 M) of 3-13 years of age with DH were studied from genetic, immunological and gastrointestinal points of view. Genetic analysis of HLA haplotypes showed and incidence of HLA B8 of 50% and DW3 of 59.3%. Immunopathology of the skin demonstrated the presence of granular IgA deposits along D.E.J. Immune complexes were present in all cases. Subtotal mucosal atrophy was present in 32% and partial atrophy in 50% of the children. 35 patients were put on a strict dietary regimen for at least 12 months. The results were as follows: jejunal mucosa became normal in all patients indipendently of HLA haplotype. Gluten challenge reinduced mucosal atrophy and mild skin lesions. Diet alone induced complete regression of the skin lesionsin 43%; in the other 57% diet did not permit complete control of the skin lesions but allowed a 50% or more reduction in the mean dose of dapsone . 5 patients treated only with dapsone showed a satisfactory respon se of the skin lesion with no effect on the jejunal mucosa.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Giunta, A., Prampolini, L., Marzorati, D. et al. 555 EFFICACY OF DIET AND DRUGS ON DERMATITIS HERPETIFORMIS (D.H.) OF CHILDHOOD. Pediatr Res 15 (Suppl 4), 533 (1981). https://doi.org/10.1203/00006450-198104001-00568
Issue Date:
DOI: https://doi.org/10.1203/00006450-198104001-00568