Abstract
This study was designed to test the hypothesis that the postnatal diuresis observed in healthy neonates during the second hour of life is due to an expansion of their extracellular volume (ECV) as a result of manual or spontaneous placental blood transfusion (Strauss, J., Daniel, S., and James, L.S., Pediatrics, In Press). Seven healthy infants were infused with isotonic glucose during the third or fourth hour of life. Plasma and urine were analyzed for osmolality, inulin and para-amino hippuric acid in order to estimate osmolal and free water clearances as well as glomerular filtration rate (GFR) and renal plasma flow (RPF). Despite individual variation in initial values and in response, glucose infusion caused a prompt diuresis which was accompanied by an increase in GFR and RPF but no consistent change in urine osmolality. The response was of short duration and the fraction of exogenous load excreted was less than 5% in five out of 7 infants. This study indicates that during the first few hours of postnatal life, the kidney of the newborn infant is capable of responding to water load as that of the older newborn. It can also be concluded that the transient postnatal diuresis observed in these infants could be partly due to the expansion of ECV by placental blood transfusion.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
James, S., Daniel, S. & Strauss, J. 253 RESPONSE TO RAPID VOLUME EXPANSION DURING THE POSTNATAL PERIOD. Pediatr Res 15 (Suppl 4), 482 (1981). https://doi.org/10.1203/00006450-198104001-00264
Issue Date:
DOI: https://doi.org/10.1203/00006450-198104001-00264