Abstract
Radioisotope labeled (85Sr and 141Ce) 15±3μ microspheres were injected into the left atrium of 9 anesthetized neonatal piglets during normoxia and normothermia, N/N, and after 30 minutes of mild hypothermia (4.5-5.0°C reduction in core temperature) and hypoxia (mean PAO2 reduction 38.7%), H/H. The cardiac index was not significantly changed. (N/N 150.8±18.1cc/kg/min, H/H 133.5 ±15.1 cc/kg/min). Most tissue blood flows appeared to be reduced; however only renal blood flow and flow to the separated mucosa with H/H and submucosa of the distal small intestine (DSI) and colon (C) were significantly reduced with p>.05. Hypoxia or hypothermia alone does not produce both the DSI and C mucosal changes with H/H. The blood flow reduction with H/H occurs in the same areas as the necrosis seen in neontal necrotizing entero-colitis (NNEC). Differential blood flow due to shunting at the submucosal and mucosal levels during H/H may be an etiologic factor in NNEC.
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Dudgeon, D., Spoon, D., Randall, P. et al. 238 THE EFFECTS OF COMBINED HYPOTHERMIA AND HYPOXIA ON KEGIONAL PERFUSION IN THE NEONATAL PIGLET. Pediatr Res 15 (Suppl 4), 479 (1981). https://doi.org/10.1203/00006450-198104001-00248
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DOI: https://doi.org/10.1203/00006450-198104001-00248