Abstract
The effect of unilateral CRYP on prolactin(PRL)binding in the CRYP and the con.lat testes was investigated in the rat. CRYP was rendered surgically at 3 weeks, and 3,6 and 9wks later PRL binding was measured in testicular homogenates. Binding decreased at 3 wks from 0.64±0.08ng/testis/100g rat in control to 0.37±0.06 in CRYP and 0.43±0.07 in con.lat testes. At 6 wks control testes bound 0.87±0.01ng/tes/100g rat, CRYP 0.12±0.01 and con.lat increased to 0.82±0.01. At 9 wks: control 0.7±0.01, CRYP 0.12±0.01 and con.lat 1.13±0.04. Orchiopexy was performed in another group of rats at 6, 9 and 12 wks of age. The 6 wks orchp. produced a slight improvement in PRL binding by the CRYP testes. The 9 and 12 wks orchp. did not improve the decreased binding. The con.lat testes bound more than did the nonorchp. con.lat. S.c. PRL in PVP, 0.5mg/kg 3 t.w. for 5 wks induced an increase in PRL binding by control, CRYP and con.lateral testes. To search into the possible mechanism of these changes one group of rats were given Smg/kg s.c. testosterone, and another-500 IU/kg HCG 3 t.w. for 5 wks. Testosterone produced a fall in PRL binding by control, CRYP and con.lat testes. HCG did not alter binding by any of these preparations. In conclusion: 1.CRYP in the rat impair PRL binding and produce a con.lat increase. 2.Orchiopexy restores PRL binding only if done before 6 wks of age. 3.The con.lat increase in PRL binding is not mediated by changes in testosterone or gonadotropine levels.
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Hochberg, Z., Amit, T., Youdim, M. et al. Prolactin receptors in the testes of cryptorchid (CRYP) rats. Pediatr Res 15, 1570 (1981). https://doi.org/10.1203/00006450-198112000-00212
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DOI: https://doi.org/10.1203/00006450-198112000-00212