Abstract
An association has been demonstrated between HLA-antigens and thyroid diseases such as Graves' disease, Hashimoto's thyroiditis and subacute thyroiditis.
The significance of HLA types in the pathogenesis of congenital hypothyroidism has not been clarified. Recently, a study from Japan showed an increased frequency of HLA-Aw24 in congenital hypothyroidism (N Engl J Med 1980; 303:226). An American study did not confirm this finding, but could not exclude the possibiloty that HLA-B18 may be increased in patients with congenital hypothyroidism (N Engl J Med 1980;303: 1177).
In a study of HLA-A, B and C types in - so far - 24 Danish patients with congenital hypothyroidism we did not find any association between the HLA types and the congenital dysplasia of the thyroid gland. In particular, the frequencies of Aw24 and B18 antigens were both lower in the patients than in the controls.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jacobsen, B., Brandt, N. & Svejgaard, A. HLA typing and congenital, primary hypothyroidism. Pediatr Res 15, 1568 (1981). https://doi.org/10.1203/00006450-198112000-00201
Issue Date:
DOI: https://doi.org/10.1203/00006450-198112000-00201