Abstract
TR (measured after 4 days of cryoactivation at -4°C) and PRA were determined by RIA, in the upright position, in 40 NTC (age 7 mo. - 15 yrs) on an "ad libitum" Na diet; 16 of them were obese (overweight > 30%). CR was calculated as TR minus PRA. Applied statistical analysis: non parametric for comparison between samples and parametric for linear first order regression.
Results: 1) TR, CR and PRA values were statistically not different in obese and normal children. 2) There was a statistically significant positive correlation between TR and PRA (p< 0.001) and between TR and CR (p < 0.001); however, no correlation was found between PRA and CR. 3). Correlation with age was not significant for TR, CR and PRA.
In conclusion, in our experience, PRA is a valuable index of TR in normotensive children, normal as well as obese. The importance of CR in different pathological situations is under investigation.
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Giovannelli, G., Ammenti, A., Nori, G. et al. Plasma renin activity (PRA), cryorenin (CR) and total renin (TR) in normotensive children (NTC). Pediatr Res 15, 1557 (1981). https://doi.org/10.1203/00006450-198112000-00132
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DOI: https://doi.org/10.1203/00006450-198112000-00132